Papers

our papers

Below are the publications in peer-reviewed scientific journals where BTK medical devices have been used. It should be noted that BTK participated as an external financier (supplier) and has no ownership of the data nor has it revealed any constraints on the publication of the data nor has it affected in any way the scientific, technical and procedural autonomy of the authors who conducted the study.

Iuxta 3D

The New Generation of Subperiosteal Implants for Patient-Specific Treatment of Atrophic Dental Arches

Subperiosteal implants were first introduced in the early 1940s for the treatment of edentulous maxillary and mandibular arches with severe bone atrophy. After achieving widespread popularity in the 80s and 90s, this denture therapy was progressively abandoned due to significant technique limitations, including high rates of infection and the complications and difficulties with positioning implants and obtaining sufficiently extensive bone impressions. In the last two decades, digital technology has dramatically changed the world of implant dentistry. In particular, modern diagnostic imaging, digital technology, and direct metal laser sintering now allow for the projection of implants with the proper extension, leading to the fabrication of custom-made titanium meshes that perfectly fit the specific anatomical requirements of patients. With modern production methods, subperiosteal implants have been digitally reinterpreted, and interest in them is being renewed for the treatment of edentulous patients with atrophic arches. This article describes the evolution of subperiosteal implants in recent years and presents two clinical cases involving the placement of new generation (NG) subperiosteal implants with the clinical and radiographic findings at the 1-year follow-up.

2024

Literature Review and Two Case Reports. Int J Periodontics Restorative Dent. 2023 Nov 3;43(6):735-741. doi: 10.11607/prd.6229. PMID: 37347616.
Vatteroni E, Covani U, Menchini Fabris GB. The New Generation of Subperiosteal Implants for Patient-Specific Treatment of Atrophic Dental Arches: Literature Review and Two Case Reports. Int J Periodontics Restorative Dent. 2023 Nov 3;43(6):735-741. doi: 10.11607/prd.6229. PMID: 37347616.

Scanske protocol

A fully digital rehabilitation for immediately loaded fixed in-terim complete-arch prosthesis: A case report

The digital workflows in implantology are becoming increasingly common, offering rehabilitation with predictable outcomes. However, there are instances where a fully digital workflow is not feasible, often requiring conventional methods such as when registering the patient’s occlusion. The present paper aimed to show a case report based on a digital workflow to make immediately loaded fixed interim complete-arch
prostheses for a patient with terminal dentition. The key innovation lies in digitally capturing the patient’s maxillo-mandibular relationship, prior to the surgical procedure, by utilizing two dedicated “skeletal scan bodies” (ScanSke) and an intraoral scanner. These ScanSke were used as reference landmarks screwed onto mini-implants. In particular, these scan bodies were scanned with the maxillary complete arch before and after implant surgery, in order to be used as reference landmarks for the superimposition of the arches before and after the implant placement, maintaining the maxillary relationship with the antagonist arch.

2024

Journal o f OSSEOINTEGRATION and Oral Rehabilitation
G. Ruggiero - Marco Serri2 , Michele Serri2 , A. Mastrosimone1 , F. Zarone1 , R. Sorrentino1

Vertical ridge augmentation with Ti-reinforced dense polytetrafluoroethylene (d-PTFE) membranes or Ti-meshes and collagen membranes: 3-year results of a randomized clinical trial

Background: The present study aimed to evaluate hard and soft tissue parameters around implants placed in augmented posterior mandible, comparing Ti-reinforced d-PTFE mem- branes with Ti-meshes covered with collagen membranes, after 3 years of follow-up. Materials and Methods: Forty eligible patients were randomly assigned to group A (Ti-reinforced d-PTFE membrane) or group B (mesh covered with collagen mem- brane) for vertical ridge augmentation (VRA) and simultaneous implants. Implants were evaluated using specific peri-implant parameters for bone and soft tissues: probing pocket depth (PPD), modified plaque index (mPI), bleeding on probing (BoP), modified gingival index (mGI), thickness of keratinized tissue (tKT), width of kerati- nized tissue (wKT), fornix depth (FD), peri-implant bone level (PBL), interproximal bone peaks (IBP), marginal bone loss (MBL), interproximal bone loss (IBL).
Results: A total of 28 patients with 79 implants were evaluated after 3 years of follow-up. The mean value of MBL was 0.70 mm (group A = 0.73 mm; group B = 0.71 mm), while mean IBL was 0.54 mm (group A = 0.64 mm; group B = 0.40 mm). The treatment with meshes resulted not inferior to PTFE and their clinical results appeared similar. A strong correlation between PBL and IBP was con- firmed. Both study groups showed an increase of tKT and wKT values.
Conclusion: In the posterior mandible, VRA using both techniques provides stable PBLs up to 3 years. A correct soft tissue management and a strict professional oral hygiene protocol play a crucial role on peri-implant health over time.

2023

Clin Implant Dent Relat Res. 2023;25:352–369.
Alessandro Cucchi DDS, MSClin, PhD1 | Sofia Bettini DDS2 | Paolo Ghensi DDS, MSClin, PhD3 | Antonino Fiorino DDS, PhD4 | Giuseppe Corinaldesi DDS, MD, MSClin5

HYDROXYAPATITE AND BETA-TRICALCIUM PHOSPHATE IN THE SOCKET PRESERVATION: PRESENTATION OF CLINICAL CASES.

Riabilitazione di un mascellare gravemente atrofico mediante approccio digitale: GBR con griglia in titanio customizzata e chirurgia implantare computer-guidata

2022

CAD CAM 3_2022
Alessandro Cucchi*, Lucia Tedeschi**, Gianluca Migliorini***, Sofia Bettini°

HYDROXYAPATITE AND BETA-TRICALCIUM PHOSPHATE IN THE SOCKET PRESERVATION: PRESENTATION OF CLINICAL CASES.

“M. Di Girolamo, D. Mazza, S. Volpe, G. Stelitano, L. Volpe, F. Cecchetti. HYDROXYAPATITE AND BETA-TRICALCIUM PHOSPHATE IN THE SOCKET PRESERVATION: PRESENTATION OF CLINICAL CASES. Eur J Musculoskel Dis 2023 May-Aug; 12(2): 77-85

2023

European Journal of Musculoskeletal Diseases
M. Di Girolamo, D. Mazza, S. Volpe, G. Stelitano, L. Volpe, F. Cecchetti.

Sinus lift, innovative crestal approach: the “Rialto” technique.

To illustrate a new, minimally invasive surgical procedure for the elevation of the
maxillary sinus mucosa via the transcrestal route, insertion of biomaterial and simultaneous implant placement, when the bone thickness below the sinus is limited (≥ 5mm)

2022

Dental Cadmos
Volpe Stefano, M.D.

(Italiano) Material characterization and bacterial interaction of titanium discs produced by selective laser melting

Additive manufacturing Antimicrobials/antimicrobial resistance Implant dentistry/implantology Materials science(s)
Biofilm(s)

2022

Materials Characterization 189 (2022) 111989
C. Mangano

(Italiano) Artificial intelligence and augmented reality in implant planning

Technology is now pervasive in dentistry, and implantology is no ex- ception. Intra-oral and face scanners, CBCT and digital condylographs allow us to acquire 3D images and videos of our patients, useful not only for diag- nosis but also for treatment planning. The patient becomes virtual.

2022

29th EAO Annual Scientific Meeting · Geneva
Francesco Mangano

3d Mesh

Vertical and horizontal ridge augmentation using customized CAD/CAM titanium mesh with versus without resorbable membranes. A randomized clinical trial

The aim was to evaluate the role of resorbable membranes applied over
customized titanium meshes related to soft tissue healing and bone regeneration after
vertical/horizontal bone augmentation.

2021

IUXTA-3D

(Italiano) Custom-made 3D printed subperiosteal titanium implants for the prosthetic restoration of the atrophic posterior mandible of elderly patients: a case series

Retrospective clinical study; 1 year F-UP; Iuxta-3D succes rate

2020

3D Printing in Medicine (2020) 6:1
Mangano C, Bianchi A, Mangano F.G., Dana J. Colombo M., Solop I., Admakin O.

3D MESH

Clinical and volumetric outcomes after vertical ridge augmentation using computer-aided-design/computer-aided manufacturing (CAD/CAM) customized titanium meshes: a pilot study

One of the most recent innovations in bone augmentation surgery is represented by computer- aided-design/computer-aided-manufacturing (CAD/CAM) customized titanium meshes, which can be used to restore vertical bone defects before implant-prosthetic rehabilitations. The aim of this study was to evaluate the effectiveness/reliability of this technique in a consecutive series of cases.

2020

BCM Oral Health
Alessandro Cucchi , Alessandro Bianchi , Paolo Calamai , Lisa Rinaldi , Francesco Mangano , Elisabetta Vignudelli1 and Giuseppe Corinaldesi1

SAFE BL

Histological and histomorphometric analysis of bone tissueafter guided bone regeneration with non-resorbablemembranes vs resorbable membranes and titanium mesh

GBR succes rate; GBR bone quality; implant success rate.

2019

Clin Implant Dent Relat Res.2019;21:693–701
Cucchi A.; Sartori M.; Parrilli A..; Vignudelli E.; Corinaldesi G.

SAFE BL

Combining Intraoral and Face Scans for the Design and Fabrication of Computer-Assisted Design/Computer-Assisted Manufacturing (CAD/CAM) Polyether-Ether-Ketone (PEEK) Implant-Supported Bars for Maxillary Overdentures

Retrospective clinical study; 1 year F-UP; implant succes rate; Intraoral scanning efficency; CAD-CAM structures efficency

2018

Scanning Volume 2019, Article ID 4274715, 14 pages
Francesco Mangano ,Carlo Mangano, Bidzina Margiani, and Oleg Admakin

EVO EI

Clinical outcomes of implants placed in ridge-preserved versusnonpreserved sites: A 4-year randomized clinical trial

Multicenter clinical trial; 4 years F-UP; implant succes rate; graft site healing;

2018

Clin Implant Dent Relat Res. 2018 Dec;20(6):906-914 doi: 10.1111/cid.12682
Marconcin S; Giammarinaro E; Derchi G; Alfonsi F; Covani U; Barone A

IUXTA -3D

Custom-Made Direct Metal Laser Sintering Titanium Subperiosteal Implants: A Retrospective Clinical Study on 70 Patients

Retrospective clinical study; 2 year F-UP; Iuxta-3D succes rate

2018

BioMed Research International, vol. 2018, Article ID 5420391, 11 pages, 2018.
Cerea M., Dolcini G. A.

IUXTA -3D

Impianti sottoperiostei: le implicazioni della progettazione virtuale e dell’osteosintesi rigida

Clinical case;
Digital work-flow

2018

ScanningVolume 2019, Article ID 4274715, 14 pages
Negrini S., Daleffe F.

SAFE BL; OXOFIX; BWB

The Ball Welding Bar: A New Solution for the Immediate Loading of Screw-Retained,Mandibular Fixed Full Arch Prostheses

Prospective study; 2 year F-UP; Osteointegration success rate; Biocompatibility; BWB success rate.

2017

International Journal of Dentistry; Volume 2017, Article ID 2679085, 9 pages; https://doi.org/10.1155/2017/2679085
Bacchiocchi D. and Guida A.

ANALOGHI, SCAN BODIES, SCANNER INTRAORALE

Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study

In vitro study; Digital scanning accuracy.

2017

BMC Oral Health (2017) 17:92
Imburgia M., Logozzo S., Hauschild U., Veronesi G., Mangano C., Mangano F.

SAFE BL

GBR With D-PTFE Ti-reinforced membranes versus Ti-meshes and collagen membranes.

Randomized comparative clinical trial; 9 months F-UP; GBR surgery success rate; Osteointegration success rate; Biocompatbility.

2017

J Dent Res 2017; 96 (Suppl B): 3050.
Cucchi A, Natali A, Corinaldesi G, Marchetti C.

PTERIGO

Evaluation of pterygoid implants with partial or full-arch rehabilitations.

Randomized comparative clinical trial; 9 months F-UP; GBR surgery succes rate; Osteointegration success rate; Biocompatbility.

2017

J Dent Res 2017; 96 (Suppl B): 205
Cucchi A, Natali A, Corinaldesi G, Marchetti C.

SAFE BL

Evaluation of soft tissues and peri-implant parameters after GBR in posterior mandible.

Randomized comparative clinical trial; 9 months F-UP; GBR surgery succes rate; Osteointegration success rate; Biocompatbility.

2017

Clin Implant Oral Res 2017; 28; S14: 289 doi: 10.1111/clr.288_13042
Cucchi A, Cinquegrana C, Rocchi E, Corinaldesi G, Marchetti C.

SAFE BL

(Italiano) Histological and micro-CT evaluation of bone tissue after guided bone regeneration (GBR)

Randomized comparative clinical trial; 9 months F-UP; GBR surgery succes rate; Osteointegration success rate; Biocompatbility;

2017

Clin Implant Oral Res 2017; 28; S14: 23. doi: 10.1111/clr.22_13040.
Cucchi A, Cinquegrana C, Vignudelli E, Corinaldesi G, Marchetti C.

SAFE BL

Tapered, Double-Lead Threads Single Implants Placed in Fresh Extraction Sockets and Healed Sites of the Posterior Jaws: A Multicenter Randomized Controlled Trial with 1 to 3 Years of Follow-Up

Multicenter randomized Controlled trial; 1 to 3 yo follow-up Osteointegration succes rate; Biocompatiblity.

2017

Biomed Res Int. 2017; 2017: 8017175. doi: 10.1155/2017/8017175
Cucchi A, Vignudelli E, Franco S, Levrini L, Castellani D, Pagliani L, Rea M, Modena C, Sandri G, Longhi C.

SAFE BL

Evaluation of implant stability and complication rates after guided bone regenration with non-resorbable membranes versus titanium mesh. A randomized clinical trial.

Randomized comparative clinical trial; 1 year F-UP; GBR surgery succes rate; Primary stability; Osteointegration success rate; Biocompatbility.

2017

Clin Implant Dent Relat Res. 2017; 19(5): 821-832. doi: 10.1111/cid.12520
Cucchi A, Vignudelli E, Napolitano A, Marchetti C, Corinaldesi G.

EVO EI

Tissue changes after ridge preservation with two xenografts: preliminary results from a multicentre randomized controlled clinical trial

Multicenter clinical trial; 3 months F-UP; graft site healing; Implant insertion in healed site.

2017

J Clin Periodontol. 2017 Feb;44(2):204-214. doi: 10.1111/jcpe.12655. Epub 2017 Jan 10.
A. Barone, P. Toti, A. Quaranta, F. Alfonsi, A. Cucchi, J. L. Calvo-Guirado, Bruno Negri, R. Di Felice, U. Covani

SAFE BL

A minimally-invasive approach based on Pterygoid and short implants for rehabilitation of extremely atrophic maxilla: a case report.

Clinical case; 1 year F-UP; Osteointegration succes rate; Biocompatibility.

2017

Implant Dent. 2017 Aug;26(4): 639-644; DOI: 10.1097/ID. 0000603
Cucchi A.; Franco S.; Vignudelli E.; Corinaldesi G.

BTK 3D system (SAFE BL)

Full digital worklow nella pratica quotidiana in implantologia. Studio clinico prospettico

Prospective study; 1 year F-UP; Osteointegration succes rate; Biocompatibility.

2016

CAD/CAM; 2016; 2
F. Mangano; F. Luongo; G. Luongo; C. Mangano

BTK 3D system (SAFE BL)

From guided surgery to final Prosthesis: a prospective clinical study on 15 Partially Edentulous Patients

Prospective study; 6 months F-UP; Osteointegration succes rate; Biocompatibility.

2016

International Journal of Dentistry Volume 2016, Article ID 7358423, 7 pages
G. A. Dolcini; M. Colombo; C. Mangano

KONIC EI

Early bone response To Dual Acid-Etched and machined Dental Implant Placed in the Poterior Maxilla:a histological study in human jaws.

Histological study in human; 2 months F-UP; Histological images bone around implant; BIC% BDTA% BD%; Biocompatibility.

2016

Implant Dent. 2016; Nov; 16(1)
Mangano F.; Jefferson Trabach Pires; Jamil Awad Shibli; Eitan Mijiritsky; Giovanna Iezzi; Adriano Piattelli; Mangano C.

SAFE BL

Evaluation of primary and secondary stability of single implants placed in fresh extraction sockets: a clinical trial

Clinical trial; 3 years F-UP; Osteointegration success rate; Biocompatibility.

2016

Biotechnology & Biotechnological Equipment; 2016; 30:2; 354-359
N. De Angelis, E. Sorrenti, C. Modena, S. Benedicenti

EVO EI

Volumetric analysis of remodelling pattern after ridge preservation comparing use of two types of xenografts. A multicentre randomized clinical trial

Multicenter clinical trial; 3 months F-UP; graft site healing; Implant insertion in healed site.

2016

Clin Oral Implants Res. 2016 Nov;27(11):105-115
A. Barone, P. Toti, A. Quaranta, F. Alfonsi, A. Cucchi, J. L. Calvo-Guirado, Bruno Negri, R. Di Felice, U. Covani.

BTK SURFACE MACHINED & ETCHED

Gene Expression of Human Mesenchymal Stem Cells Cultured on Titanium Dental Implant Surfaces

In vitro study; genes expression; osteoinduction; Citotoxicity.

2016

J Craniofac Surg 2016 May;27(3):712-7
Barone A., Toti P, Bertossi D, Marconcini S, De Santis D, Nocini PF, Iurlaro A, Alfonsi F, Covani U.

SAFE BL

Comparative Clinical and histological Assesment of Dental Implants Delivered with a Manual Torque Limiting Wrench versus with an Electronally Controlled Torque limiting device

Pre-clinical study in animal; 2 months F-UP; Primary stability; Histological images bone around implant; BIC%; Biocompatibility.

2015

Int J Periodontics Restorative Dent. 2015 Nov-Dec;35(6):819-23
M. Nevins, N. De Angelis

BTK TITANIUM GRADE IV e V

Expression of SP7, RUNX1, DLX5 and CTNNB1 in human mesenchymal stem cells cultured on Xenogeneic Bone Substitute as Compared to Machined Titanium

In vitro study; genes expression; osteoinduction; citotoxicity

2014

Implant Dent 2014;23:1–9
A. Barone, P. Toti, N. Funel, D. Campani, U. Covani.

KORUM (i.e.EVO) EI + EE

Evaluation of bacterial leakage and microgap along the implant-abutment interface of two different implant connection designs

In vitro study; Implant-abutment sealing; Bacterial leakage.

2012

Egyptian Dental Journal, January 2012 (Part III); Volume 58
Nesma Mohammed, Magdy El-Gohary.

TRE (i.e. KLASSIC) EE

Maxillary sinus lift through heterologous bone grafts and simultaneous acid-etched implants placement. Five year follow-up

Retrospective Study; 5 years F-UP; Osteointegration success rates; Biocompatibility.

2008

MINERVA CHIR 2008;63:79-91
D. Stievano, D. A. di Stefano, M. Ludovichetti, S. Pagnutti, F. Gazzola, C. Boato, E. Stellini

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Papers

Papers

our papers

The New Generation of Subperiosteal Implants for Patient-Specific Treatment of Atrophic Dental Arches

A fully digital rehabilitation for immediately loaded fixed in-terim complete-arch prosthesis: A case report

Vertical ridge augmentation with Ti-reinforced dense polytetrafluoroethylene (d-PTFE) membranes or Ti-meshes and collagen membranes: 3-year results of a randomized clinical trial

HYDROXYAPATITE AND BETA-TRICALCIUM PHOSPHATE IN THE SOCKET PRESERVATION: PRESENTATION OF CLINICAL CASES.

HYDROXYAPATITE AND BETA-TRICALCIUM PHOSPHATE IN THE SOCKET PRESERVATION: PRESENTATION OF CLINICAL CASES.

Sinus lift, innovative crestal approach: the “Rialto” technique.

(Italiano) Material characterization and bacterial interaction of titanium discs produced by selective laser melting

(Italiano) Artificial intelligence and augmented reality in implant planning

Vertical and horizontal ridge augmentation using customized CAD/CAM titanium mesh with versus without resorbable membranes. A randomized clinical trial

(Italiano) Custom-made 3D printed subperiosteal titanium implants for the prosthetic restoration of the atrophic posterior mandible of elderly patients: a case series

Clinical and volumetric outcomes after vertical ridge augmentation using computer-aided-design/computer-aided manufacturing (CAD/CAM) customized titanium meshes: a pilot study

Histological and histomorphometric analysis of bone tissueafter guided bone regeneration with non-resorbablemembranes vs resorbable membranes and titanium mesh

Combining Intraoral and Face Scans for the Design and Fabrication of Computer-Assisted Design/Computer-Assisted Manufacturing (CAD/CAM) Polyether-Ether-Ketone (PEEK) Implant-Supported Bars for Maxillary Overdentures

Clinical outcomes of implants placed in ridge-preserved versusnonpreserved sites: A 4-year randomized clinical trial

Custom-Made Direct Metal Laser Sintering Titanium Subperiosteal Implants: A Retrospective Clinical Study on 70 Patients

Impianti sottoperiostei: le implicazioni della progettazione virtuale e dell’osteosintesi rigida

The Ball Welding Bar: A New Solution for the Immediate Loading of Screw-Retained,Mandibular Fixed Full Arch Prostheses

Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study

GBR With D-PTFE Ti-reinforced membranes versus Ti-meshes and collagen membranes.

Evaluation of pterygoid implants with partial or full-arch rehabilitations.

Evaluation of soft tissues and peri-implant parameters after GBR in posterior mandible.

(Italiano) Histological and micro-CT evaluation of bone tissue after guided bone regeneration (GBR)

Tapered, Double-Lead Threads Single Implants Placed in Fresh Extraction Sockets and Healed Sites of the Posterior Jaws: A Multicenter Randomized Controlled Trial with 1 to 3 Years of Follow-Up

Evaluation of implant stability and complication rates after guided bone regenration with non-resorbable membranes versus titanium mesh. A randomized clinical trial.

Tissue changes after ridge preservation with two xenografts: preliminary results from a multicentre randomized controlled clinical trial

A minimally-invasive approach based on Pterygoid and short implants for rehabilitation of extremely atrophic maxilla: a case report.

Full digital worklow nella pratica quotidiana in implantologia. Studio clinico prospettico

From guided surgery to final Prosthesis: a prospective clinical study on 15 Partially Edentulous Patients

Early bone response To Dual Acid-Etched and machined Dental Implant Placed in the Poterior Maxilla:a histological study in human jaws.

Evaluation of primary and secondary stability of single implants placed in fresh extraction sockets: a clinical trial

Volumetric analysis of remodelling pattern after ridge preservation comparing use of two types of xenografts. A multicentre randomized clinical trial

Gene Expression of Human Mesenchymal Stem Cells Cultured on Titanium Dental Implant Surfaces

Comparative Clinical and histological Assesment of Dental Implants Delivered with a Manual Torque Limiting Wrench versus with an Electronally Controlled Torque limiting device

Expression of SP7, RUNX1, DLX5 and CTNNB1 in human mesenchymal stem cells cultured on Xenogeneic Bone Substitute as Compared to Machined Titanium

Evaluation of bacterial leakage and microgap along the implant-abutment interface of two different implant connection designs

Maxillary sinus lift through heterologous bone grafts and simultaneous acid-etched implants placement. Five year follow-up

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